Decades of research have unequivocally shown that life stress is a central factor in the onset and course of almost every psychiatric disorder. However, the processes by which stress influences mental health are complex, and the integration of the myriad of biological and psychological systems involved requires a multidisciplinary perspective. Fortunately, scientists working from diverse vantage points have made huge advances in unpacking the complexities of stress-disorder relations. The Oxford Handbook of Stress and Mental Health provides a comprehensive, up-to-date overview of the science of stress and mental health. Topics covered include assessment issues, the role of stress in various mental disorders, developmental influences and individual difference factors that predict reactivity to stress, and treatment of stress-related mental health problems. Internationally recognized scholars in the field of stress and stress-related disorders have contributed their diverse expertise, providing both depth and breadth in terms of understanding stress and mental health. Chapters 1 to 4 provide a critical discussion of assessment issues in the domains of stress exposure and stress response. Chapters 5 to 14 review the relation of stress exposures to a broad range of mental health outcomes across the lifespan. Chapters 15 to 25 are concerned with understanding how the stress response unfolds at both psychological and neurobiological levels. Lastly, Chapters 26 to 33 addresses stress adaptation and resilience, as well as evidence-based treatments for stress and stress-related disorder. This volume will constitute an invaluable resource for students, established scientists, and clinicians looking for a comprehensive treatment of the topic of stress and mental health.