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Genetics: From Genes to Genomes Leland Hartwell

Genetics:  From Genes to Genomes By Leland Hartwell

Genetics: From Genes to Genomes by Leland Hartwell


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Summary

This text looks at four major themes related to genetics: the central importance of the genome; the application of genetics to the human; the growing appreciation for the relationships among organisms arising from genetic research; and the impact of biotechnology.

Genetics: From Genes to Genomes Summary

Genetics: From Genes to Genomes by Leland Hartwell

The authors have developed a text that reflects the directions Genetics is taking as it heads into the 21st century. This perspective embraces five major themes:1. the central importance of the genome, as opposed to the action of individual genes;2. the application of genetics to the improvement of human health;3. the growing appreciation for the relationships among organisms arising from genetic research; 4. the impact of biotechnology on the accelerating growth of genetic knowledge; and5. the importance of emerging social and ethical issues related to our use of biotechnology.

About Leland Hartwell

Dr. Leland Hartwell is President and Director of Seattles Fred Hutchinson CancerResearch Center and Professor of Genome Sciences at the University of Washington.Dr. Hartwells primary research contributions were in identifying genes that controlcell division in yeast, including those necessary for the division process as well asthose necessary for the fi delity of genome reproduction. Subsequently, many of thesesame genes have been found to control cell division in humans and oft en to be thesite of alteration in cancer cells.Dr. Hartwell is a member of the National Academy of Sciences and has receivedthe Albert Lasker Basic Medical Research Award, the Gairdner FoundationInternational Award, the Genetics Society Medal, and the 2001 Nobel Prize inPhysiology or Medicine. Dr. Hood received an MD from the Johns Hopkins Medical Schooland a PhD in Biochemistry from the California Institute of Technology. His research interests include immunology, development and the development of biological instrumentation (e.g. the protein sequenator and the automated fluorescent DNA sequencer). His research played a key role in unraveling the mysteries of anitbody diversity. Dr. Hood has taught molecular evolution, immunology, molecular biology and biochemistry. he is currently the Chairman (and founder) of the cross-disciplinary Department of Molecular Biotechnology at the University of Washington. Dr. Hood has received a variety of awards including the Albert Lasker Award for Medical Research (1987), Dickson Price (1987), Cefas Award for Biochemistry (1989), and the Distinguished Service Award from the national Association of Teachers (1998). He is deeply involved in K-12 science educatiohn. His hobbies include running, mountain climbing, and reading. Dr. Michael Goldberg is a professor at Cornell University, where he teaches introductorygenetics and human genetics. He was an undergraduate at Yale Universityand received his Ph.D. in biochemistry from Stanford University. Dr. Goldberg performedpostdoctoral research at the Biozentrum of the University of Basel (Switzerland)and at Harvard University, and he received an NIH Fogarty Senior InternationalFellowship for study at Imperial College (England) and fellowships from theFondazione Cenci Bolognetti for sabbatical work at the University of Rome (Italy).His current research uses the tools of Drosophila genetics and the biochemical analysisof frog egg cell extracts to investigate the mechanisms that ensure proper cellcycle progression and chromosome segregation during mitosis and meiosis. Dr. Silver is a Professor at Princeton University in the Departments of Molecualr Biology, Ecology and Evolutionary Biology, and the program in Neuroscience. Dr. silver graduated from the University of Pennsylvania with BA and MS degrees in physics, and from Harvard University with a PhD in biophysics. He was a research fellow at the Sloan-Kettering Institute for Cancer Research and a seniro scientist at Cold Harbor Lab before coming to Princeton. He is the author of Remaking Eden: Cloning and Beyond in a Brave New World. He is also the co-editor-in-chief of a new international journal entitled Clining: Science and Policy, and co-editor-in-chief of Mammalian Genome, the official journal of the International Mammalian Genome society. In 1993, Dr. Silver was elected a Fellow fo the AAAS. Ruth Veres is a science writer and editor with 25 years of experience in textbook publishing. She obtained her BA from Swarthmore college and MA degrees from Columbia University in NY and Tufts University. In addition to developing and editing more than 30 texts in the fields of political science, economics, psychology, nutrition, chemistry, and biology, she has co-authored a book on the immune system and an introductory biology text. She has also taught writing and languages at the Univ of California at Berkeley. She lives in San Francisco with her husband. Dr. Reynolds is an educator and author who has been teaching genetics and biology since 1990. An affiliate faculty member of the Genetics Department at the University of Washington, her research has included studies of gene regulation in E. coli, chromosome structure and DNA replication in yeast, and chloroplast gene expression in marien algae. She is a graduate of Mount Holyoke College and received her PhD from Tufts University. Dr. Reynolds was a post doctoral research fellow witht he Harvard University Department of Molecular Biology. Dr. Reynolds was also an author and producer of the laserdisc and CD-ROM Genetics: Fundamentals to Frontiers.

Table of Contents

I Basic Principles: How Traits are Transmitted1 Mendel's Breakthrough: Patterns, Particles, and Principles of Heredity2 Extension to Mendel for Single-Gene Inheritance3 The Chromosome Theory of Inheritance4 Linkage, Recombination, and the Mapping of Genes on ChromosomesII What Genes Are and What They Do5 DNA: How the Molecule of Heredity Carries, Replicates, and Recombines Information6 Anatomy and Function of a Gene: Dissection Through Mutation7 Gene Expression: The Flow of Genetic Information from DNA via RNA to ProteinIII Using Genetic Engineering to Unravel the Information in Genomes8 DNA at High Resolution: Use of DNA Cloning, PCR, and Hybridization as the Tools of Genetic Analysis9 The Direct Detection of Genotype10 The Mapping and Analysis of GenomesIV How Genes Travel11 The Eukaryotic Chromosome: An Organelle for Packaging and Managing DNA12 Chromosomal Rearrangements and Changes in Chromosome Number Reshape Eukaryotic Genomes13 The Prokaryotic Chromosome: Genetic Analysis in Bacteria14 The Chromosomes of Organelles Outside the Nucleus Exhibit Non-Mendelian Patterns of InheritanceV How Genes Are Regulated15 Gene Regulation in Prokaryotes16 Gene Regulation in Eukaryotes17 Cell-Cycle Regulation and the Genetics of CancerVI Gene Regulation and Development: Portraits of Model Eukaryotic OrganismsUsing Genetics to Study Development: An Introduction to the Genetic Portraits18 Saccharomyces cerevisiae: A Genetic Portrait of Yeast19 Arabidopsis Thaliana: Genetic Portrait of A Model Plant20 Caenorhabditis elegans: Genetic Portrait of a Simple Multicellular Animal21 Drosophila melanogaster: Genetic Portrait of the Fruit Fly22 Mus musculus: A Genetic Portrait of the House MouseVII How Genes Change23 The Genetic Analysis of Populations and How They Evolve24 Evolution at the Molecular LevelEpilogue Human Genetics and the Future of BiologyAppendix A Guidelines for Gene NomenclatureAppendix B Brief Answers Section

Additional information

GOR005085908
9780075409236
0075409232
Genetics: From Genes to Genomes by Leland Hartwell
Used - Very Good
Hardback
McGraw-Hill Education - Europe
19990916
800
N/A
Book picture is for illustrative purposes only, actual binding, cover or edition may vary.
This is a used book - there is no escaping the fact it has been read by someone else and it will show signs of wear and previous use. Overall we expect it to be in very good condition, but if you are not entirely satisfied please get in touch with us

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