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Applications of Antisense Therapies to Restenosis LeRoy E. Rabbani

Applications of Antisense Therapies to Restenosis By LeRoy E. Rabbani

Applications of Antisense Therapies to Restenosis by LeRoy E. Rabbani


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Applications of Antisense Therapies to Restenosis Summary

Applications of Antisense Therapies to Restenosis by LeRoy E. Rabbani

Restenosis, the proliferation of smooth muscle cells (SMC) that line blood vessels, often follows angioplasty. Despite advances in cardiology, restenosis continues to affect up to 40% of the over 500,000 patients who undergo angioplasty each year. Applications of Antisense Therapies to Restenosis is the first volume to address the potential of using antisense therapies to inhibit the restenosis that occurs after percutaneous transluminal angioplasty and coronary stenting. The work critically examines the application of various antisense therapies for inhibiting restenosis.

Table of Contents

1. Restenosis: The Clinical Problem; A.D. Simon, et al. 2. The Pathobiology of Restenosis. A Paradigm from Clinical and Experimental Studies; J.L. Januzzi, E.R. Edelman. 3. Coronary Repair and Restenosis. Cellular Basis for Antisense Approaches; A. Zalewski, et al. 4. Vascular Smooth Muscle Cell Biology and Restenosis; J.A. Leopold, J. Loscalzo. 5. Vascular Antisense Therapy Directed Against c-myc, c-myb, and PCNA; M. Husain, M. Simons. 6. Phosphorothioate Oligodeoxynucleotides as Inhibitors of Gene Expression: Antisense and Non-Antisense Effects; I.V. Lebedeva, C.A. Stein. 7. Molecular Therapies for Vascular Disease: Altering the Balance Between Cell Growth and Cell Death; G.H. Gibbons. 8. Oligonucleotides Containing the G-Quartet Sequence Motif; J.R. Wyatt, C.A. Stein. 9. Non-G-Quartet, Non-Sequence Specific Antirestonitic Effects of Phosphorothioate Oligodeoxynucleotides; L.E. Rabbani, et al. 10. Local Delivery of Antirestenotic Drugs; D.E. Drachman, et al. 11. Critical Considerations and Future Directions; M.R. Bennett, S.M. Schwartz.

Additional information

NLS9781461373612
9781461373612
1461373611
Applications of Antisense Therapies to Restenosis by LeRoy E. Rabbani
New
Paperback
Springer-Verlag New York Inc.
2012-10-12
184
N/A
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