In the waning days of the 16th century, English alchemist and astrologer John Dee flees to Prague, pursued by a terrifying demon. It is a time of strife and persecution, when darkness and chaos threaten to overcome the forces of light and reason. Dee seeks out Rabbi Judah Loew and assists him in creating a Golem, a magical man fashioned from clay. Together they begin a desperate search to find the fabled 36th Righteous Man, for ancient prophecies foretell that if the last righteous man dies, the world will end...and dark spirits will make it in their own image.