Massimiliano Simons provides the first systematic study of Serress work in the context of 20th-century French philosophy of science. By proposing new readings of Serress philosophy, Simons creates a synthesis between his predecessors, Gaston Bachelard, Georges Canguilhem and Louis Althusser as well as contemporary Francophone philosophers of science such as Bruno Latour and Isabelle Stengers. Simons situates Serress unique contribution through his notion of the quasi-object, a concept, he argues, organizes great parts of Serress work into a promising philosophy of science as well as a challenge to the narrower field of French epistemology, to which it has often been limited. Simons highlights how the concept encompasses Serress commitment to positive relations between science and culture and his rejection of pleas to purify the scientific self from imaginative and cultural elements. It helps to situate Serres between the distinct traditions of Bachelard and Latour as well as progressing the innovative aspects of Serress philosophy for current debates in the philosophy, history and sociology of science. Showing how Serress philosophy can serve as a normative approach to science and technology, Michel Serres and French Philosophy of Science takes in themes of materiality, religiosity, modernity and ecology to advance a timely alternative to philosophy of science for contemporary life.