The Rat as Animal Model in Breast Cancer Research: A histopathological study of radiation- and hormone-induced rat mammary tumors by Matthew J. van Zwieten
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The Rat as Animal Model in Breast Cancer Research
The Rat as Animal Model in Breast Cancer Research
The Rat as Animal Model in Breast Cancer Research Summary
Table of Contents
1 Introduction.- 1.1 Breast Cancer - An Overview.- 1.2 Purpose of the Study.- 2 Animals and Experimental Methodology.- 2.1 Rationale for Choice of Rat Strains.- 2.2 Origin of the Rats.- 2.3 Selected Biological Characteristics of the Rats.- 2.3.1 Growth Curves.- 2.3.2 Breeding Data.- 2.3.3 Selected Immunogenetic Data.- 2.4 Husbandry Conditions.- 2.5 Irradiation.- 2.6 Hormone Administration.- 2.7 Castration.- 2.8 Clinical Examination.- 2.9 Necropsy Procedures.- 2.10 Statistical Evaluation.- 3 Effects of Irradiation and Hormone Administration on Mammary Tumor Incidence.- 3.1 Introduction.- 3.2 Experimental Data.- 3.3 Crude Mammary Tumor Incidence Results.- 3.4 Dose-Effect Relationships.- 3.5 Conclusions.- 4 Normal Anatomy and Pathology of the Rat Mammary Gland.- 4.1 The Normal Mammary Gland.- 4.1.1 Anatomic Considerations.- 4.1.2 Histological Structure.- 4.1.3 Development.- 4.2 Pathological Changes - A Classification.- 4.3 Nonneoplastic Lesions.- 4.4 Neoplastic Lesions.- 4.4.1 Benign Mammary Tumors.- 4.4.2 Malignant Mammary Tumors.- 4.5 Histogenesis and Interrelationships of Certain Mammary Gland Lesions.- 4.6 Discussion.- 4.6.1 Histological Types of Rat Mammary Neoplasms.- 4.6.2 Malignancy of the Rat Mammary Carcinoma.- 5 Correlation of Mammary Tumor Histology with Experimental Procedures.- 5.1 Introduction.- 5.2 Tumor Types and Treatment Relationships.- 5.3 Topographical Distribution of Mammary Tumors.- 5.4 Discussion.- 6 Lesions of the Pituitary Gland and Liver.- 6.1 Introduction.- 6.2 Pituitary Gland.- 6.2.1 Background Remarks.- 6.2.2 Morphological Aspects.- 6.2.3 Effect of Irradiation and/or Estrogen Administration on Pituitary Tumor Incidence.- 6.2.4 Interrelationships Between Pituitary Tumors, Plasma Prolactin Levels and Mammary Tumors.- 6.2.5 Discussion.- 6.3 Liver.- 6.3.1 Background Remarks.- 6.3.2 Morphological Aspects.- 6.3.3 Results.- 6.3.4 Discussion.- 7 General Discussion, Including a Brief Review of Animal Models in Breast Cancer Research.- 7.1 Synthesis.- 7.2 Brief Review of Animal Models in Breast Cancer Research.- 7.2.1 Definition of an Animal Model.- 7.2.2 The Rat.- 7.2.3 The Mouse.- 7.2.4 The Dog.- 7.2.5 The Cat.- 7.2.6 Nonhuman Primates.- 7.2.7 Other Species.- 7.2.8 Conclusions.- Summary.- Acknowledgments.- References.
Additional information
NPB9780898386240
9780898386240
0898386241
The Rat as Animal Model in Breast Cancer Research: A histopathological study of radiation- and hormone-induced rat mammary tumors by Matthew J. van Zwieten
New
Hardback
Kluwer Academic Publishers
1984-01-31
292
N/A
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