Lieutenant Horatio Caine leads a crack team of forensic scientists who investigate crimes amid the tropical surroundings and cultural crossroads of Miami. Together, they collect and analyze the evidence to expose the truth and to bring justice to those who often cannot speak for themselves: the victims.

Crime boss Kurt Wallace was fighting to hold his vast crime empire together -- until a few well-placed bullets ended the struggle. As a host of dangerous "business interests" move in to seize control of Wallace's piece of the Miami underworld, Caine's CSIs must piece together the evidence to discover who was responsible for the crime that all of Miami had a motive to commit.