London 1666 - A terrible plague has swept through the city and people live in fear of animals carrying the disease.

Woofer is a loveable stray who works in the palace kitchen and Tiger Lily is the pampered pet spaniel of King Charles II. They come from very different worlds but this hasn't stopped them becoming the best of friends and looking out for each other. When Woofer finds himself in trouble he has to escape the palace grounds and Tiger Lily isn't far behind him.

It's not long before a new danger emerges - a great fire is sweeping across London destroying everything in its path. Can these two brave dogs survive the blazing fire and make their way to safety?