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Statistical Thinking in Clinical Trials Michael A. Proschan (National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA)

Statistical Thinking in Clinical Trials By Michael A. Proschan (National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA)

Summary

The authors present the essence of statistical reasoning in clinical trials,peppered with well-known clinical trials This book uses only a small number of important principles to develop the entire statistical foundation of clinical trials.

Statistical Thinking in Clinical Trials Summary

Statistical Thinking in Clinical Trials by Michael A. Proschan (National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA)

  • Uses a relatively small number of key principles, in conjunction with a modest repertoire of statistical techniques to help the reader master the essential statistical aspects of clinical trials
  • Includes a wealth of famous examples in cancer, cardiovascular diseases, and infectious diseases
  • Readers with a familiarity of undergraduate statistics will be well-prepared for the book. When more advanced results are needed, they will be motivated in a heuristic way.

Statistical Thinking in Clinical Trials Reviews

The goal of the book Statistical Thinking in Clinical Trials is to engender statistical intuition that can be used in different types of clinical trials, and author Michael A. Proschan brilliantly achieved the goal. The biggest part of the book is dedicated to re-randomization tests, which can be applied in a multitude of settings. The author shows their beauty and simplicity. To illustrate theoretical explanations, the author uses examples of real trials. There are not many examples of trials, but the author returns to them in different chapters and at the end of studying the book, readers become familiar with these examples. I think, it is a positive aspect of the book and provides a better understanding of the practical application of the techniques described in the book than the use of many different examples during the presentation of the material. It should be noted that author uses examples not only to show the correct methods used in trials, but also to show possible mistakes that may occur during the trial and how to avoid them. [...] I would recommend [this book] for biostatisticians who not only intent on deeper learning statistical techniques but are also interested in improvement of statistical intuition and using it in different types of clinical trials.
-Maria Ivanchuk, in ISCB News, June 2022

About Michael A. Proschan (National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA)

Michael Proschan is a mathematical statistician and Fellow of the American Statistical Association with 32 years of clinical trial experience in cardiovascular and infectious diseases, including HIV/AIDS, Ebola virus disease, and COVID-19. He has expertise in statistical monitoring of clinical trials, having taught short courses and co-authored the book Statistical Monitoring of Clinical Trials: A Unified Approach with Gordon Lan and Janet Wittes. He co-authored, with Sally Hunsberger, one of the first papers on adaptive clinical trial methods using the observed treatment effect at an interim analysis. More recently, Dr. Proschan has written about the vital role re-randomization tests play in adaptive methods before breaking the treatment blind. He has recently been an adjunct faculty member at George Washington University and Johns Hopkins University's Advanced Academic Programs.

Table of Contents

1. Evidence and Inference. 2. 2 x 2 Tables. 3. Introduction to Clinical Trials. 4. Design of Clinical Trials. 5. Randomization/Allocation. 6. Randomization-Based Inference7 Survival Analysis. 7. Sample Size/Power. 8. Monitoring. 9. M&Ms: Multiplicity & Missing Data. 10. Adaptive Methods.

Additional information

NPB9781138058590
9781138058590
1138058599
Statistical Thinking in Clinical Trials by Michael A. Proschan (National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA)
New
Hardback
Taylor & Francis Ltd
2021-11-24
264
N/A
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