This text provides an understanding of the pathophysiological basis of metabolic disease essential for the effective use of biochemical tests in clinical practice. With extensive use of case histories, it seeks to relate the basic science to actual clinical experience. An up-to-date approach is used, and the text shows the link between pure biochemistry and the pathophysiology of disease, offering an integrated approach to learning. Key point boxes throughout the book provide a revision aid for major topics, there are 100 flow diagrams, and clear schematic representations of pathological processess emphasize important concepts.