One in Three is the coming-of-age story of James Hartman, a young doctor struggling with the demands of endless hours on call in NHS hospitals. Set in 1989 against the backdrop of the unfolding AIDS epidemic, James is continually confronted by tragedy, pain, and death

During his early weeks, James realises he inadvertently caused a patients death and attempts to conceal his mistake. Exhausted and unable to cope, he seeks solace in Southamptons redlight district.

As his first-year passes, there are brief moments of triumph, but James impulsive decisions pave the way for future complications. Amidst the chaos, a glimmer of hope emerges when he meets Ainslie, a trainee surgeon from New Zealand. James becomes besotted with her, falling madly in love. However, shadows from his past resurface, threatening his newfound happiness and future.