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Green Chemistry in Drug Discovery Paul F. Richardson

Green Chemistry in Drug Discovery By Paul F. Richardson

Green Chemistry in Drug Discovery by Paul F. Richardson


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Summary

This detailed book highlights several emerging areas in the implementation of green chemistry in medicinal chemistry drug discovery with a specific focus on their application to the expeditious discovery of new biologically active entities.

Green Chemistry in Drug Discovery Summary

Green Chemistry in Drug Discovery: From Academia to Industry by Paul F. Richardson

This detailed book highlights several emerging areas in the implementation of green chemistry in medicinal chemistry drug discovery with a specific focus on their application to the expeditious discovery of new biologically active entities. Divided into three sections, the collection explores greener approaches to chemical transformations that are both prevalent and have been highlighted as challenging within the pharmaceutical industry, overall synthetic strategy, as well as the implementation and impact of a range of enabling technologies within medicinal chemistry. As a volume of the Methods in Pharmacology and Toxicology series, chapters provide the kind of key insight that can guide researchers toward greater success in the lab.
Authoritative and practical, Green Chemistry in Drug Discovery: From Academia to Industry provides both a fundamental insight into the progress that has been made as well as some of the challenges that still exist for these techniques to be effectively implemented in the drug discovery process in a routine manner.

About Paul F. Richardson

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Table of Contents

Part I: Greener Approaches to Classical Transformations

1. Green Synthesis of Common Heterocycles

Christian Schafer, Hyejin Cho, and Bela Toeroek

2. Greener Methods for Amide Bond Synthesis

Nathan J. Oldenhuis, Aaron M. Whittaker, and Vy M. Dong

3. Mitsunobu Reactions in Medicinal Chemistry and Development of Practical Modifications

Tsuyoshi Taniguchi

4. Direct Nucleophilic Substitution of Alcohols by Bronsted or Lewis Acids Activation: An Update

Pier Giorgio Cozzi, Andrea Gualandi, Luca Mengozzi, Elisabetta Manoni, and Claire Margaret Wilson

5. Friedel-Crafts Reactions

Grigoriy Sereda

6. Ionic Liquids: Design and Applications

Arturo Obregon-Zuniga and Eusebio Juaristi

Part II: Synthetic Strategy

7. Designing Efficient Cascade Reactions in Drug Discovery

Chenguang Yu, He Huang, Chunquan Sheng, and Wei Wang

8. Multicomponent Synthesis: Cohesive Integration of Green Chemistry Principles

Razvan Cioc, Eelco Ruijter, and Romano V.A. Orru

9. Direct C-H Functionalization Approaches to Pharmaceutically Relevant Molecules

James J. Mousseau and Antonia F. Stepan

10. C-H Activation with Photoredox Catalysis

Joel W. Beatty and Corey R.J. Stephenson

11. In Situ Protecting Groups for Chemoselective Transformations

Alan Steven

Part III: Enabling Technologies

12. Expanding the Biocatalysis Toolbox

Rajesh Kumar, Carlos A. Martinez, and John W. Wong

13. New Directions in Coupling Chemistry

Gary M. Gallego, Rebecca A. Gallego, and Paul F. Richardson

14. Flow Chemistry as an Enabling Technology for Synthetic Organic Chemistry

Nicholas E. Leadbeater

15. Reaction Optimization: A High-Throughput Experimentation Approach

Simon Berritt and Jason R. Schmink

16. Radiopharmaceutical Discovery with 11CO2-Fixation Methods Inspired by Green Chemistry

Benjamin H. Rotstein and Neil Vasdev

Additional information

NLS9781071620335
9781071620335
1071620339
Green Chemistry in Drug Discovery: From Academia to Industry by Paul F. Richardson
New
Paperback
Springer-Verlag New York Inc.
2021-12-14
617
N/A
Book picture is for illustrative purposes only, actual binding, cover or edition may vary.
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