This monograph is devoted to the study of Koethe-Bochner function spaces, an active area of research at the intersection of Banach space theory, harmonic analysis, probability, and operator theory. A number of significant results---many scattered throughout the literature---are distilled and presented here, giving readers a comprehensive view of the subject from its origins in functional analysis to its connections to other disciplines. Considerable background material is provided, and the theory of Koethe-Bochner spaces is rigorously developed, with a particular focus on open problems. Extensive historical information, references, and questions for further study are included; instructive examples and many exercises are incorporated throughout. Both expansive and precise, this book's unique approach and systematic organization will appeal to advanced graduate students and researchers in functional analysis, probability, operator theory, and related fields.