Meeting the complex needs of some of the most vulnerable populations in our society often involves the need for connected networks of care providing health, social care, educational and voluntary sector services. This presents major challenges for both clients and practitioners for this to work well. Adaptive mentalization based integrative treatment (AMBIT) has been developed over the last 15 years to address the needs of both clients and practitioners in trying to make this work well. The basic framework for AMBIT was set out by the authors in AMBIT: A Guide for Teams to Develop Systems of Care in 2017 but continues to evolve through collaboration with practitioners across the world who work with people (both young people and adults) for whom many current services are not experienced as helpful. AMBIT for People with Multiple Needs: Applications in Practice describes the progress of this collaboration and shows how AMBIT has been applied in health, social care and education settings across the world. Contributors convey the detail of what it is like to apply AMBIT to their work by combining case illustrations with detailed descriptions of therapeutic practice and technique, along with inspiring and remarkable stories of therapeutic change. The chapters examine therapeutic casework in very different services providing community and residential based care with adults and young people across Europe and the UK. With AMBIT constantly evolving, the book explores recent developments in the AMBIT model and provides rich new thinking about how helping services can be supported to provide meaningful help and change.