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Aptamers Engineered Nanocarriers for Cancer Therapy Summary

Aptamers Engineered Nanocarriers for Cancer Therapy by Prashant Kesharwani, PhD (Assistant Professor, Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India)

Aptamers Engineered Nanocarriers for Cancer Therapy details the selection technologies, biological characteristics, and clinical uses of aptamer-based nano agents for cancer therapeutics. The book helps facilitate speedy solutions for some of the problems pertaining to the manufacture of nano-aptamers - such as toxicity, thermal stability, cost efficiency, tumor penetration and blood stability. Key chapters cover cell-SELEX technology for aptamer selection, mechanisms of multi-drug resistance of cancer, the relevance of aptamers as anticancer therapies, as well as the broad range of aptamer-functionalized nanostructures available. This book provides exciting insights into this relatively new approach to cancer therapeutics, and will be of interest to materials scientists, biomedical engineers, molecular biologists, biochemists and clinical scientists, with a focus on cancer therapy.

About Prashant Kesharwani, PhD (Assistant Professor, Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India)

Dr. Prashant Kesharwani is an assistant professor of pharmaceutics at the School of Pharmaceutical Education and Research, Jamia Hamdard University, New Delhi, India. He has more than 12 years of teaching, research, and industrial experience at international levels from various countries, including the United States, Malaysia, and India. An overarching goal of his current research is the development of nanoengineered drug delivery systems for various diseases. He is a recipient of many research grants from various funding bodies. He is also a receipt of several internationally acclaimed awards such as the most prestigious Ramanujan Fellowship Award from the Science and Engineering Research Board, Government of India. He has presented many invited talks and oral presentations at prestigious scientific peer-conferences, received international acclaims and awards for research contribution, supervised students/junior researchers and actively participated in outreach and scientific dissemination for the service of wider community. He actively participates in outreach and scientific dissemination for the service of the wider community.

Table of Contents

1. Cell-SELEX technology for aptamer selection 2. Biological characteristics of aptamers 3. Mechanisms of multi-drug resistance of cancer 4. Relevance of aptamers as targeting ligands for anticancer therapies 5. Aptamers as smart ligands for nano-carriers cancer targeting 6. Aptamer-functionalized liposomes for targeted cancer therapy 7. Aptamer-functionalized micelles for targeted cancer therapy 8. Aptamer-functionalized nanoparticles for targeted cancer therapy 9. Aptamer-functionalized PLGA nanoparticles for targeted cancer therapy 10. Aptamer-functionalized silica nanoparticles for targeted cancer therapy 11. Aptamer-functionalized gold nanoparticles for targeted cancer therapy 12. Aptamer-functionalized dendrimers for targeted cancer therapy 13. Aptamer-functionalized carbon nanotubes for targeted cancer therapy 14. Aptamer-functionalized quantum dots for targeted cancer therapy 15. Cancer immunotherapy via nucleic acid aptamers 16. Aptamer-based imaging and diagnostics for cancer cells 17. Microdevice-based aptamer sensors 18. Aptamer-based microfluidics for circulating tumor cells 19. Aptamer-based theranostic approaches for treatment of cancer 20. Challenges of aptamers as targeting ligands for anticancer therapies 21. Clinical use and future perspective of aptamers

Additional information

NLS9780323858816
9780323858816
0323858813
Aptamers Engineered Nanocarriers for Cancer Therapy by Prashant Kesharwani, PhD (Assistant Professor, Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India)
New
Paperback
Elsevier Science Publishing Co Inc
2022-09-28
556
N/A
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