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Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition Richard B. Silverman (Northwestern University, Evanston, IL, USA)

Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition By Richard B. Silverman (Northwestern University, Evanston, IL, USA)

Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition by Richard B. Silverman (Northwestern University, Evanston, IL, USA)


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Summary

Deals with the general mechanisms involved in chemical reactions involving enzymes. This book: illustrates the organic mechanism associated with each enzyme-catalyzed reaction; makes the connection between organic reaction mechanisms and enzyme mechanisms; and, compiles the information about molecular mechanisms of enzyme reactions.

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Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition Summary

Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition by Richard B. Silverman (Northwestern University, Evanston, IL, USA)

The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather a book on the general mechanisms involved in chemical reactions involving enzymes. An enzyme is a protein molecule in a plant or animal that causes specific reactions without itself being permanently altered or destroyed. This is a revised edition of a very successful book, which appeals to both academic and industrial markets.

Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition Reviews

Praise for the First Edition: Silverman's newest contribution will serve as an outstanding text and reference on the reaction mechanisms of enzymes. ... His treatment of the topic should also appeal to a broad range of organic, medicinal, and biological chemists who desire an up-to-date and succinct overview of the field. Silverman should be congratulated ... should quickly become the standard for mechanistic studies. --JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

About Richard B. Silverman (Northwestern University, Evanston, IL, USA)

Professor Richard B. Silverman received his B.S. degree in chemistry from The Pennsylvania State University in 1968 and his Ph.D. degree in organic chemistry from Harvard University in 1974 (with time off for a two-year military obligation from 1969-1971). After two years as a NIH postdoctoral fellow in the laboratory of the late Professor Robert Abeles in the Graduate Department of Biochemistry at Brandeis University, he joined the chemistry faculty at Northwestern University. In 1986, he became Professor of Chemistry and Professor of Biochemistry, Molecular Biology, and Cell Biology. In 2001, he became the Charles Deering McCormick Professor of Teaching Excellence for three years, and since 2004 he has been the John Evans Professor of Chemistry. His research can be summarized as investigations of the molecular mechanisms of action, rational design, and syntheses of potential medicinal agents acting on enzymes and receptors. His awards include DuPont Young Faculty Fellow (1976), Alfred P. Sloan Research Fellow (1981-1985), NIH Research Career Development Award (1982-1987), Fellow of the American Institute of Chemists (1985), Fellow of the American Association for the Advancement of Science (1990), Arthur C. Cope Senior Scholar Award of the American Chemical Society (2003), Alumni Fellow Award from Pennsylvania State University (2008), Medicinal Chemistry Hall of Fame of the American Chemical Society (2009), the Perkin Medal from the Society of Chemical Industry (2009), the Hall of Fame of Central High School of Philadelphia (2011), the E.B. Hershberg Award for Important Discoveries in Medicinally Active Substances from the American Chemical Society (2011), Fellow of the American Chemical Society (2011), Sato Memorial International Award of the Pharmaceutical Society of Japan (2012), Roland T. Lakey Award of Wayne State University (2013), BMS-Edward E. Smissman Award of the American Chemical Society (2013), the Centenary Prize of the Royal Society of Chemistry (2013), and the Excellence in Medicinal Chemistry Prize of the Israel Chemical Society (2014). Professor Silverman has published over 320 research and review articles, holds 49 domestic and foreign patents, and has written four books (The Organic Chemistry of Drug Design and Drug Action is translated into German and Chinese). He is the inventor of LyricaTM, a drug marketed by Pfizer for epilepsy, neuropathic pain, fibromyalgia, and spinal cord injury pain; currently, he has another CNS drug in clinical trials.

Table of Contents

Enzymes as Catalysts Group Transfer Reactions: Hydrolysis, Amination, Phosphorylation Reduction and Oxidation Monooxygenation Dioxygenation Substitutions Carboxylations Decarboxylation Isomerizations Eliminations and Additions Aldol and Claisen Reactions and Retroreactions Formylations, Hydroxymethylations, and Methylations Rearrangements Appendix I Enzyme Kinetics Appendix II Problems and Solutions

Additional information

CIN0126437319G
9780126437317
0126437319
Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition by Richard B. Silverman (Northwestern University, Evanston, IL, USA)
Used - Good
Hardback
Elsevier Science Publishing Co Inc
20020307
736
N/A
Book picture is for illustrative purposes only, actual binding, cover or edition may vary.
This is a used book - there is no escaping the fact it has been read by someone else and it will show signs of wear and previous use. Overall we expect it to be in good condition, but if you are not entirely satisfied please get in touch with us

Customer Reviews - Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition