I. Introduction 1. Introduction - Robert I. Fox and Carla M. Fox 2. A Note from Sweden: Recollection of Henrik Sjoegren - Elke Theander and Frank A.Wollheim 3. Myths, Pearls, and Tips Regarding Sjoegren's Syndrome - Robert I. Fox, and Manuel Ramos-Casals, and John H. Stone 4. Information for Referring Physicians and Patients - Robert I. Fox and Carla M. Fox - II. Classification Criteria and Disease Status Activity, Histology of Salivary Gland Biopsy, and Imaging 5. Current Concepts on Classification Criteria and Disease Status Indexes in Sjoegren's Syndrome - Claudio Vitali, Chiara Baldini, and Stefano Bombardieri 6. Histopathology and Glandular Biopsies in Sjoegren's Syndrome - Roland Jonsson, Kathrine Skarstein, and Malin V. Jonsson 7. Imaging Technology in Sjoegren's Syndrome: Non-invasive Evaluation of the Salivary Glands - Jonn Terje Geitung and Malin V. Jonsson - III. Mechanisms of Pathogenesis 8. Genomics and Viruses in Sjoegren's Syndrome - Kathy L. Moser and John B. Harley 9. Autoantibodies and Autoantigens in Sjoegren's Syndrome - Kazuhisa Nozawa, Minoru Satoh, Seunghee Cha, Yoshinari Takasaki, and Edward K.L. Chan 10. B-cell Epitopes of Sjoegren's Syndrome Related Autoantigens Ro/SSA and La/SSB - Athanasios G. Tzioufas, John G. Routsias, and Haralampos M. Moutsopoulos 11. Neurobiology and Hormonal Control of Lacrimal and Salivary Gland Function - Yrjoe T. Konttinen, Alberto Vivo Porcar, Pauliina Porola, Katja Koskenpato, Maria Lores Rodriguez, Raimo Poellanen, Vasily Stegaev, Liisa Virkki, Michelle Spaan, and Beata D. Przybyla - IV. Clinical and Therapeutic Considerations 12. Overview of Management of Dry Eye Associated with Sjoegren's Syndrome - Paul E. Michelson and Robert I. Fox 13. Pathogenesis: Emphasis on Dry Eye and the Role of the Lacrimal Functional Unit in Sjoegren's Syndrome - Michael E. Stern and Stephen C. Pflugfelder 14. Oral and Dental Manifestations of Sjoegren's Syndrome: Current Approaches to Diagnostics and Therapy - Malin V. Jonsson, Nicolas Delaleu, Mihaela C. Marthinussen, and Roland Jonsson 15. Emphasis on Dry Mouth and the Role of Salivary Glands - Nicolas Delaleu, Menelaos N. Manoussakis, Haralampos M. Moutsopoulos, and Roland Jonsson 16. Otolaryngology Manifestations of Sjoegren's Syndrome - Jacqui E. Allen and Peter C. Belafsky 17. Therapy of Extraglandular Manifestations of Sjoegren's Syndrome: Dermatologic, Pulmonary, Gynecologic, Fibromyalgia Manifestations; Considerations for the Surgical SS Patient - Robert I. Fox and Carla M. Fox 18. Therapy of Extraglandular Manifestations in the US - Robert I. Fox and Carla M. Fox 19. Current Treatment of Extraglandular Manifestations with Disease Modifying and Immunosuppressive Agents - Athanasios G. Tzioufas and Haralampos M. Moutsopoulos 20. Lymphoproliferation and Lymphoma in Sjoegren's Syndrome - Justin Pijpe, Hendrika Bootsma, and Guustaf W. van Imhoff 21. Fatigue, Dryness, and Quality of Life as Clinical Trial Outcomes in Primary Sjoegren's Syndrome - Simon J. Bowman 22. The Neurological Manifestations of Sjoegren's Syndrome - Robert I. Fox and Julius Birnbaum - V. The Views from Japan, China, India, and Australia 23. New Approaches for the Management of Dry Mouth in Sjoegren's Syndrome in Japan - Yoichi Nakagawa, Ichiro Saito 24. New Approaches for the Management of Dry Eye in Sjoegren's Syndrome in Japan - Kazuo Tsubota 25. Sjoegren's Syndrome in Australia: Clinical Practice and Research - Tom Gordon and Maureen Rischmueller 26. Primary Sjoegrens Syndrome: Report from India - Ramnath Misra, Sapan Pandya, and Debashish Danda 27. Sjoegren Syndrome in China - Jing He and Zhan-guo Li (Beijing) 28. Sjoegren's Syndrome in China - CS Lau (Hong Kong) 29. Sjoegren's Syndrome in Israel: A Scientific Point of View - Moshe Tishler and Yehuda Shoenfeld - VI. Future Perspectives 30. Looking Into the Future-The EULAR Disease Activity Scores: Toward a Consensual Evaluation of Primary Sjoegren's Syndrome - Raphaele Seror, Philippe Ravaud, Claudio Vitali, Simon Bowman, and Xavier Mariette 31. Looking into the Crystal Ball: Initiatives from the Sjoegren's Syndrome Foundation that Will Impact Patient Care - Elaine Alexander, Frederick B. Vivino, Steven E. Carsons, and Katherine Morland Hammitt 32. Biological Treatment for Sjoegren's Syndrome - Philip L. Cohen and Pamela Traisak 33. Looking Into the Future-Emerging Therapies Based on Pathogenesis - Jacques-Eric Gottenberg and Xavier Mariette 34. Into the Future: Autonomic Neuropathy, MicroRNAs, and Gene Therapy - Ilias Alevizos, John A. Chiorini, and Nikolay P. Nikolov