Two of the field's most respected leaders provide critical knowledge on the medical implications of co-existing pathophysiology on the management of anesthesia. Organized by disease, the 4th Edition of this popular guide has been completely revised and updated to reflect the most current information on definition, current pathophysiology, significant pre-, intra-, and post-operative factors of the disease process, anesthetic judgement, and management. Common diseases are discussed in detail, while rare diseases receive attention based on unique features that could be of importance in the perioperative period.