A. Introduction.- Hepatic Encephalopathy: The Present and the Future,.- B. Pathophysiology of Hepatic Encephalopathy.- The Role of Ammonia and Other Toxins.- Ammonia in Liver and Extrahepatic Tissues: An Overview of Metabolism and Toxicity in Mammals,.- Neurophysiology of Ammonia Intoxication,.- Effect of Portacaval Anastomosis on Ammonia Metabolism in Brain and Liver,.- Selective Inhibition of Mitochondrial Dehydrogenases by Ammonia and Fatty Acyl Coenzyme A Derivatives,.- Acute Action of Ammonia on Leucine Metabolism in Isolated Astrocytes, Neurons, and Oligo Cells of Rat Brain,.- Progressive Hyperammonemia and Insulin Resistance After Portacaval Shunt in Homozygous Familial Hypercholesterolemia,.- Mesenteric Venous Stenosis Reduces Hyperammonemia in the Portacaval Shunted Rat,.- Hyperammonemic Encephalopathy Syndrome Due to Urinary Bladder Distention and Infection.- Role of Toxins and Synergism in Hepatic Encephalopathy,.- Cerebral Metabolism and Function in Hepatic Failure.- Brain Energy Metabolism in Hepatic Encephalopathy.- In Vivo NMR Spectroscopy Studies of Cerebral Metabolism in Rats After Portacaval Shunting,.- Effects of Hypercarbia and Portacaval Shunting on Amino Acids and High Energy Phosphates of the Rat Brain: a 1H and 31P NMR Study,.- Positron-Emission Tomography in the Study of Hepatic Encephalopathy,.- The Use of Cultured Astrocytes in the Study of Hepatic Encephalopathy,.- Brain Edema in Experimental Fulminant Hepatic Failure,.- Encephalopathy of Reye's Syndrome: Studies of the Pathogenic Process in Animal Models,.- The Rat with Carbon Tetrachloride-Induced Cirrhosis as a Model of Hepatic Encephalopathy,.- GABA and Benzodiazepine Receptors in Hepatic Encephalopathy.- Hepatic Encephalopathy and Benzodiazepine Receptor Ligands,.- Detection and Characterization of Endogenous Benzodiazepine Activity in Both Animal Models and Humans with Hepatic Encephalopathy,.- Isolated CNS Neurons from a Model of Hepatic Encephalopathy Exhibit Increased Sensitivity to a Benzodiazepine,.- Studies of Central and Peripheral-Type Benzodiazepine Receptors in Autopsied Brain Tissue from Cirrhotic Patients with Hepatic Encephalopathy,.- Ro 15-1788 Kinetics are Markedly Impaired in Cirrhotic Patients,.- Plasma GABA-like Factor in Hepatic Encephalopathy May Be Taurine,.- Diazepam Metabolism in Perfused Cultures of Adult Rat Hepatocytes,.- Other Neurotransmitter Systems (amines, amino acids, peptides) in Hepatic Encephalopathy.- Hepatocerebral Dysfunction and Brain Serotonin,.- Biogenic Amines in Hepatic Encephalopathy: Evidence for Increased Serotonin Turnover in Human Brain,.- Increased Serotoninergic and Noradrenergic Activity in an Experimental Model of Hepatic Encephalopathy in Rats,.- Excitatory Amino Acids and Hepatic Encephalopathy,.- Activities of Glutamate-Related Enzymes in Autopsied Brain Tissue from Cirrhotic Patients with Hepatic Encephalopathy,.- Does Ammonia Exert its Neurotoxicity Through an Inhibition of Transmitter Glutamate Synthesis?.- Beta-Endorphin and Opiate Receptor Changes in Acute and Chronic Models of Hepatic Encephalopathy,.- C. Treatment of Hepatic Encephalopathy.- Update of Existing Therapeutic Approaches.- Treatment of Hepatic Encephalopathy. New Perspectives on Old Ideas,.- Treatment of Hepatic Encephalopathy with Lactulose and Antibiotics,.- Nutritional Therapy of Portal-Systemic Encephalopathy: The Branched-Chain Amino Acid Story,.- Nutrition, Diet, and Hepatic Encephalopathy,.- Partial Portal Decompression: Initial Clinical Experience with Small-Stoma Portacaval Shunt,.- Potential Therapeutic Use of Benzodiazepine Antagonists.- Benzodiazepine-Antagonist (Ro 15-1788) Flumazenil, Anexate (R), Pharmacokinetics, and Therapeutic Applications,.- Effects of the Benzodiazepine Antagonist Flumazenil in Hepatic Encephalopathy in Man,.- Treatment of Hepatic Encephalopathy with the Benzodiazepine Antagonist Flumazenil.