1. Role of Hemichannels in CNS Inflammation and the Inflammasome Pathway Yuri Kim, Joanne O. Davidson, Katherine C. Gunn, Anthony R. Phillips, Colin R. Green and Alistair J. Gunn 2. P2X7 Receptors as a Therapeutic Target Elena De Marchi, Elisa Orioli, Diego Dal Ben and Elena Adinolfi 3. Polymodal Transient Receptor Potential Vanilloid Type 1 (TRPV1) Nocisensor: Structure, Modulators, and Therapeutic Applications Minghua Cui, Vijayakumar Gosu, Shaherin Basith, Sunhye Hong and Sun Choi 4. TRPM8 ion Channels as Potential Cancer Biomarker and Target in Pancreatic Cancer Nelson S. Yee 5. Ion Channels In The Eye: Involvement In Ocular Pathologies Jonathan P Giblin, Nuria Comes, Olaf Strauss and Xavier Gasull 6. Calcium-Activated Potassium Channels: Potential Target for Cardiovascular Diseases De-Li Dong, Yun-Long Bai and Ben-Zhi Cai 7. The Modulation of Potassium Channels in the Smooth Muscle as a Therapeutic Strategy for Disorders of the Gastrointestinal Tract Diego Curro 8. Targeting the Channel Activity of Viroporins Janet To, Wahyu Surya and Jaume Torres 9. Contribution of Automated Technologies to Ion Channel Drug Discovery Arturo Picones, Arlet Loza-Huerta, Pedro Segura-Chama and Cesar O. Lara Figueroa