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Delivery Strategies for Antisense Oligonucleotide Therapeutics Saghir Akhtar

Delivery Strategies for Antisense Oligonucleotide Therapeutics By Saghir Akhtar

Delivery Strategies for Antisense Oligonucleotide Therapeutics by Saghir Akhtar

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Summary

With contributions from leading experts, this book is the first to focus solely on addressing the problems and reviewing the strategies currently being used to improve the delivery of antisense nucleic acids. Important delivery issues, such as improving biological stability, improving cell-specific targeting and cellular uptake.

Delivery Strategies for Antisense Oligonucleotide Therapeutics Summary

Delivery Strategies for Antisense Oligonucleotide Therapeutics by Saghir Akhtar

* The first book to focus solely on the delivery of antisense nucleic acids

* Contributions from leading scientists in the antisense field

* Review-type articles to introduce newcomers to the field

* Review-type articles linked with exciting previously unpublished data on delivery of antisense therapeutics

* Information on the state-of-the-art strategies for improved cellular and tissue delivery of antisense, antigene, and ribozyme nucleic acids

About Saghir Akhtar

Saghir Akhtar

Table of Contents

1. Preface 2. Overview of antisense oligonucleotide therapeutics and delivery 3. Disrupting the flow of genetic information with antisense oligodeoxynucleotides: research and therapeutic applications 4. Cellular delivery of ribozymes 5. Improved structural design and cellular 6. Uptake of gt-rich triplex-forming oligonucleotides 7. Pharmacokinetic and distribution studies 8. Pharmacokinetics and delivery of oligonucleotides to the brain 9. In vivo pharmacokinetics of oligonucleotides following administration by different routes 10. Improving biological stability of oligonucleotides 11. Nuclease-resistant nucleic acid therapeutics 12. Self-stabilized oligonucleotides as novel antisense agents 13. Circular oligonucleotides as potential modulators of gene expression 14. Peptide nucleic acids as antisense therapeutic agents 15. Stabilized rna analogues for antisense and ribozyme applications 16. Improving membrane transport and targeted delivery of antisense oligonucleotides 17. Uptake and localization of phosphodeister and chimeric 18. Oligodeoxynucleotides in normal and leukaemic primary cells 19. Oligonucleotide transport across membranes and into cells: effects of chemical modifications 20. Liposomes as a delivery system for antisense and ribozyme compounds 21. Intracellular delivery of oligonucleotides with cationic liposomes 22. The delivery of oligonucleotides using ph-sensitive liposomes 23. Enhancing endsosomal exit of nucleic acids using ph-sensitive viral fusion peptides 24. Targeted delivery of anti-hepatitis b antisense oligonucleotides 25. Design, synthesis, and cellular delivery of antibody antisense oligonucleotide conjugates for cancer therapy

Additional information

NLS9781138558571
9781138558571
1138558575
Delivery Strategies for Antisense Oligonucleotide Therapeutics by Saghir Akhtar
Saghir Akhtar
CRC Press Revivals
New
Paperback
Taylor & Francis Ltd
2019-01-25
318
N/A
Book picture is for illustrative purposes only, actual binding, cover or edition may vary.
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