Now in its sixth edition, Principles of Gene Manipulation provides an excellent introduction to the area of genetic engineering of plants, animals and microbes for advanced level undergraduates, with a basic understanding of genetics. This classic textbook has been substantially updated and revised to reflect the rapid advances that have been made in the core technologies in the seven years since the last edition. Furthermore, to put these technologies into context, the final chapter has been structured into six themes:* nucleic acids as diagnostic tools* new drugs and new therapies for genetic diseases* combating infectious disease* protein engineering* metabolic engineering* modern plant breedingA website is now available to complement this text, at www.blackwellpublishing.com/primrose