Evidence Based Medicine provides a clear explanation of the central questions: how to ask answerable clinical questions; how to translate them into effective searches for the best evidence; how to critically appraise that evidence for its validity and importance; and how to integrate it with patients' values and preferences. New edition of fantastically successful book on evidence-based medicine written by the best-known authorities in the world. Focuses on the major challenge of practicing evidence medicine in real clinical settings, providing tips and tools to help achieve this. Book comes complete with access to both CD-ROM and web site providing appropriate tools to download plus additional content. Set of ready reference cards included in book. New chapter on knowledge translation. Increase number and scope of electronic tools available both on CD-ROM and website. Major revison of chpaters on diagnosis and teaching.