These two volumes contain eighteen invited papers by distinguished mathematicians in honor of the eightieth birthday of Israel M. Gelfand, one of the most remarkable mathematicians of our time. Gelfand has played a crucial role in the development of functional analysis during the last half-century. His work and his philosophy have in fact helped shape our understanding of the term 'functional analysis'. The papers in these volumes largely concern areas in which Gelfand has a very strong interest today, including geometric quantum field theory, representation theory, combinatorial structures underlying various 'continuous' constructions, quantum groups and geometry.