One of the world's most celebrated scholars, Stephen Greenblatt has crafted both an innovative work of history and a thrilling story of discovery, in which one manuscript, plucked from a thousand years of neglect, changed the course of human thought and made possible the world as we know it.

Nearly six hundred years ago, a short, genial, cannily alert man in his late 30s took a very old manuscript off a library shelf, saw with excitement what he had discovered, and ordered that it be copied. The book was the last surviving manuscript of an ancient Roman philosophical epic, On the Nature of Things, by Lucretius -- a thrillingly beautiful poem of the most dangerous of ideas: that the universe functioned without the aid of gods, that religious fear was damaging to human life, and that matter was made up of very small particles in eternal motion.

The copying and translation of this ancient book, the greatest discovery of the greatest book-hunter of his age, fueled the Renaissance, inspiring artists such as Botticelli and thinkers such as Giordano Bruno, shaping the thoughts of Galileo and Freud, Darwin and Einstein, and influencing writers from Montaigne to Thomas Jefferson.