First published in 2002. Routledge is an imprint of Taylor & Francis, an informa company.

Introduction, Overview, Catching Up on Schizophrenia: Natural History and Neurobiology, A Unitary Model of Schizophrenia, Implications of Normal Brain Development for the Pathogenesis of Schizophrenia, Epidemiology, Lifetime Prevalence, Demographic Risk Factors, and Diagnostic Validity of Nonaffective Psychosis as Assessed in a US Community Sample, Obstetric Complications and the Risk of Schizophrenia, Effects of Family History and Place and Season of Birth on the Risk of Schizophrenia, Genetics, The Types and Prevalence of Mental Illness in the Biological and Adoptive Families of Adopted Schizophrenics, An Independent Analysis of the Danish Adoption Study of Schizophrenia, Genetics of Schizophrenia and the New Millennium: Progress and Pitfalls, Effect of COMT Val 108/158 Met Genotype on Frontal Lobe Function and Risk of Schizophrenia, Natural History, Epidemiology and Natural History of Schizophrenia, Stability and Course of Neuropsychological Deficits in Schizophrenia, Predictors of Relapse following Response from a First Episode of Schizophrenia or Schizoaffective Disorder, Brain Development, Progressive Cortical Change during Adolescence in Childhood-Onset Schizophrenia: A Longitudinal MagneticResonance Imaging Study, Childhood Onset Psychotic Disorders: Magnetic Resonance Imaging of Volumetric Differences in Brain Structure, Neurobiology of Disease, Lamina-Specific Alterations in the Dopamine Innervation of the Prefrontal Cortex in Schizophrenic Subjects, Absence of Neurodegeneration and Neural Injury in the Cerebral Cortex in a Sample of Elderly Patients with Schizophrenia, Selective Deficits in Prefrontal Cortex Function in Medication-Naive Patients with Schizophrenia, Thalamic Volumes in Patients with First-Episode Schizophrenia, Decreased Dendritic Spine Density on Prefrontal Cortical Pyramidal Neurons in Schizophrenia, The Emerging Role of Glutamate in the Pathophysiology and Treatment of Schizophrenia, Cortical Abnormalities in Schizophrenia Identified by Structural Magnetic Resonance Imaging, The Neuropathology of Schizophrenia: A Critical Review of the Data and Their Interpretation, Single Photon Emission Computerized Tomography Imaging of Amphetamine-Induced Dopamine Release in DrugFree Schizophrenic Subjects, Compromised White Matter Tract Integrity in Schizophrenia Inferred from Diffusion Tensor Imaging, Decreased Prefrontal Dopamine D1 Receptors in Schizophrenia Revealed by PET, Neuronal and Glial Somal Size in the Prefrontal Cortex: A Postmortem Morphometric Study of Schizophrenia and Huntington Disease, The Reduced Neuropil Hypothesis: A Circuit Based Model of Schizophrenia, Anatomical Abnormalities in the Brains of Monozygotic Twins Discordant for Schizophrenia, Treatment, The Psychosocial Treatment of Schizophrenia: An Update, Reversal of Antipsychotic-Induced Working Memory Deficits by Short-Term Dopamine D1 Receptor Stimulation, Clozapine for the Treatment-Resistant Schizophrenic: A Double-Blind Comparison with Chlorpromazine, Clinical and Theoretical Implications of 5-HT2 and D2 Receptor Occupancy of Clozapine, Risperidone, and Olanzapine in Schizophrenia, Antipsychotic Treatment Induces Alterations in Dendrite- and Spine-Associated Proteins in Dopamine-Rich Areas of the Primate Cerebral Cortex, Age at Onset and Gender of Schizophrenic Patients in Relation to Neuroleptic Resistance, Acknowledgments