Table of Contents Preface Contributors List Section I Ketogenic Diet for Epilepsy in the Clinic Eric Kossoff, MD, Section Editor Chapter 1 Overview- Ketogenic Diets and Pediatric Epilepsy: An Update Eric Kossoff, MD Chapter 2 'Alternative' Ketogenic Diets Elizabeth Neal, RD, MSc, PhD Chapter 3 Dietary Therapy in Adults: History, Demand, and Results Emily L. Johnson, MD and Mackenzie C. Cervenka, MD Chapter 4 How Do You Implement the Diet? Christina Bergqvist, MD Chapter 5 Glut1 Deficiency and the KD Joerg Klepper, MD, PhD Chapter 6 Ketogenic Diet in Established Epilepsy Indications Ann Bergin, MD, MB, ScM, MRCP Chapter 7 Ketogenic Diet for Other Epilepsies David T. Hsieh, MD and Elizabeth A. Thiele, MD, PhD Chapter 8 The Ketogenic Diet and Related Therapies in "Novel" Situations: Idiopathic Generalized Epilepsy Syndromes Sudha Kilaru Kessler MD, MSCE Chapter 9 Ketogenic Diet in Status Epilepticus Rima Nabbout, MD, PhD Chapter 10 Preventing Side Effects and Diet Discontinuation Cherie L. Herren, MD and Rana R. Said, MD Section II Ketogenic Diet - Emerging Clinical Applications and Future Potential Jong M. Rho, MD, Section Editor Chapter 11 Overview: Expanded Uses of Ketogenic Therapies Jong M. Rho, MD Chapter 12 Metabolism-Based Treatments to Counter Cancer: Scientific Rationale Thomas N. Seyfried, PhD and Laura Shelton, PhD Chapter 13 Ketogenic Diet as Adjunctive Therapy for Malignant Brain Cancer Eric C. Woolf, PhD and Adrienne C. Scheck, PhD Chapter 14 Metabolic Therapy for Autism Spectrum Disorder and Co-Morbidities Ning Cheng, PhD, Susan A. Masino, PhD, and Jong M. Rho, MD Chapter 15 Glucose and Ketone Metabolism in the Aging Brain: Implications for Therapeutic Strategies to Delay the Progression of Alzheimer's Disease Stephen C. Cunnane, PhD, Alexandre Courchesne-Loyer, MSc, Valerie St-Pierre, BSc, Camille Vandenberghe, PhD, Etienne Croteau, PhD, and Christian-Alexandre Castellano, PhD Chapter 16 Ketogenic Diet and Ketones for the Treatment of Traumatic Brain and Spinal Cord Injury Femke Streijger, PhD, Ward T. Plunet, PhD, and Wolfram Tetzlaff, MD, Dr.Med, PhD Chapter 17 Anti-Inflammatory Effects of a Ketogenic Diet: Implications for New Indications Nina Dupuis, PhD and Stephane Auvin, MD, PhD Chapter 18 Dietary Therapy for Neurological Disorders: Focus on Amyotrophic Lateral Sclerosis, Parkinson's Disease, Mood Disorders, and Migraine Carl E. Stafstrom, MD, PhD Section III Ketogenic Diet in the Laboratory Detlev Boison, PhD Section Editor Chapter 19 Overview of Ketogenic Diet in the Laboratory: Progress on Models and Mechanisms Detlev Boison PhD Chapter 20 Ketogenic Diet and PPARg Timothy A. Simeone, PhD Chapter 21 Ketogenic Diet in a Hippocampal Slice: Models and Mechanisms Masahito Kawamura, Jr, PhD Chapter 22 Metabolic Therapy and Pain David N. Ruskin, PhD Chapter 23 Ketogenic Diet, Adenosine, Epigenetics, and Antiepileptogenesis Theresa A. Lusardi, PhD and Detlev Boison, PhD Chapter 24 Ketogenic Diet, Aging, and Neurodegeneration Kui Xu, MD, PhD, Joseph C. LaManna, PhD and Michelle A. Puchowicz, PhD Chapter 25 Endocrine and Reproductive Effects of Ketogenic Diets Jacob P. Harney, PhD, Kathryn Gudsnuk, MS, Ami Patel, MD Anantha R. Vellipuram, MD, Sathyajit Bandaru, MS and David Butler, PhD Chapter 26 Alzheimer's Disease: Causes and Treatment Richard L. Veech, MD, PhD, DPhil and M. Todd King Chapter 27 Mitigation of Damage from Reactive Oxygen Species and Ionizing Radiation by Ketone Body Esters William Curtis, Martin Kemper, PhD, Alexandra Miller, PhD, Robert Pawlosky, PhD, M. Todd King, and Richard L. Veech, MD, PhD, DPhil Chapter 28 Metabolic Seizure Resistance via BAD and KATP Channels Juan Ramon Martinez-Francois, PhD, Nika Danial, PhD, and Gary Yellen, PhD Chapter 29 Lactate Dehydrogenase: A Novel Metabolic Target Nagisa Sada, PhD and Tsuyoshi Inoue, PhD Chapter 30 Effects of the Ketogenic Diet on the Blood-Brain Barrier Manoj Banjara, PhD and Damir Janigro, PhD Section IV Ketone-Based Metabolism: General Health and Metabolic Alternatives Dominic P. D'Agostino, PhD Section Editor Chapter 31 Overview of Ketone-Based Metabolism: General Health and Metabolic Alternatives Dominic P. D'Agostino, PhD Chapter 32 Ketone Supplementation for Health and Disease Angela M. Poff, PhD, Shannon L. Kesl, PhD, and Dominic P. D'Agostino, PhD Chapter 33 Identifying the Molecular Mechanism of the MCT (Ketogenic) Diet Matthew C. Walker, PhD and Robin S.B. Williams, PhD Chapter 34 Triheptanoin in Epilepsy and Beyond Karin Borges, PhD Chapter 35 Amino Acids in the Treatment of Neurological Disorders Adam L. Hartman, MD Chapter 36 2-Deoxyglucose: Metabolic Control of Seizures through Inhibition of Glycolysis Carl E. Stafstrom, MD, PhD and Thomas P. Sutula, MD, PhD Chapter 37 Ketogenic Diets as Highly Effective Treatments for Diabetes Mellitus and Obesity Eric C. Westman, MD, MHS, Emily Maguire, MSc, and William S. Yancy Jr., MD, MHS Chapter 38 Keto-Adaptation in Health and Fitness Parker Hyde, CSCS, CISSN, Vincent J. Miller, PhD, and Jeff S. Volek, PhD, RD Chapter 39 Advancing the Awareness and Application of Ketogenic Therapies Globally: The Charlie Foundation and Matthew's Friends Beth Zupec-Kania, RD, CD, Jim Abrahams, Emma Williams, MBE, Susan A. Masino, PhD
