In this issue of Veterinary Clinics: Small Animal Practice, guest editors Drs. Thomas K. Graves and Chen Gilor bring their considerable expertise to the topic of Diabetes Mellitus in Cats and Dogs. Top experts in the field cover key topics such as hypoglycemia and autonomic failure in dogs; anesthetic considerations in dogs and cats with diabetes mellitus; insulin therapy in dogs and cats; hypersomatotropism and other causes of insulin resistance in cats; and more. Contains 14 relevant, practice-oriented topics including diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome in dogs and cats; diabetes mellitus and the kidneys; continuous glucose monitoring in dogs and cats: applying new technology to an old problem; the role of nutrition in diabetes mellitus therapy; the future of diabetes therapies: ultra-long-acting insulin, smart insulin, novel GLP-1 analogs, SGLT-2 inhibitors and beta cell replacement therapy; and more. Provides in-depth clinical reviews on diabetes mellitus in cats and dogs, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.