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Human Molecular Genetics Tom Strachan (Newcastle University, UK)

Human Molecular Genetics By Tom Strachan (Newcastle University, UK)

Human Molecular Genetics by Tom Strachan (Newcastle University, UK)

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Summary

Now in its third edition, Human Molecular Genetics continues to provide authoritative guidance on the principles underlying human molecular genetics. The content and organisation has been fully revised.

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Human Molecular Genetics Summary

Human Molecular Genetics by Tom Strachan (Newcastle University, UK)

Professors Tom Strachan & Andrew Read awarded the Education Award 2007 of the ESHG for their outstanding contribution to the dispersal of knowledge of modern human molecular genetics among students and professionals.

Following the completion of the Human Genome Project the content and organization of the third edition of Human Molecular Genetics has been thoroughly revised.

* Part One (Chapters 1-7) covers basic material on DNA structure and function, chromosomes, cells and development, pedigree analysis and the basic techniques used in the laboratory.
* Part Two (Chapters 8-12) discusses the various genome sequencing projects and the insights they provide into the organisation, expression, variation and evolution of our genome.
* Part Three (Chapters 13-18) focuses on mapping, identifying and diagnosing the genetic causes of mendelian and complex diseases and cancer.
* Part Four (Chapters 19-21) looks at the wider horizons of functional genomics, proteomics, bioinformatics, animal models and therapy.

There are new chapters on cells and development and on functional genomics. The sections on complex diseases have been completely rewritten and reorganized, as has the chapter on Genome Projects. Other changes include a new section on molecular phylogenetics (Chapter 12) and the introduction of 'Ethics Boxes' to discuss some of the implications of the new knowledge. Virtually every page has been revised and updated to take account of the stunning developments of the past four years since the publication of the last edition of Human Molecular Genetics.

Features:
* Integration of Human Genome Project data throughout the book
* Two new chapters 'Cells and Development' (Chapter 3) and 'Beyond the Genome Project: Functional Genomics, Proteomics and Bioinformatics' (Chapter 19)
* Completely rewritten and reorganised coverage of complex disease genetics
* Increased emphasis on gene function and on applications of genetic knowledge, including ethical issues
* More prominence given to novel approaches to treating disease, such as cell-based therapies, pharmacogenomics, and personalised medicine
* Special topic boxes that include detailed coverage of ethical, legal and social issues, including eugenics, genetic testing and discrimination, germ-line gene therapy and genetic enhancement, and human cloning
* Contains two indices: a general index and one that contains names of diseases and disorders

Supplements:

Art of HMG3 (CD-ROM) 0-8153-4183-0: GBP34.00

Human Molecular Genetics Reviews

This book is an excellent companion for students in human genetics or for researchers that want to gain background and knowledge in this field. (Human Genetics Journal)

About Tom Strachan (Newcastle University, UK)

Professors Tom Strachan & Andrew Read awarded the Education Award 2007 of the ESHG for their outstanding contribution to the dispersal of knowledge of modern human molecular genetics among students and professionals. Tom Strachan is Scientific Director of the Institute of Human Genetics and Professor of Human Molecular Genetics at the University of Newcastle. Tom's early research interests were in multigene family evolution and interlocus sequence exchange, notably in the HLA and 21-hydroxylase gene clusters. While pursuing the latter, he became interested in medical genetics and disorders of development. His most recent research has been on the molecular genetics of early mammalian development, and focuses on building an electronic atlas of gene expression in early human development and investigating the function of inversin, a major determinant of the left-right axis. Andrew Read is a Professor of Human Genetics at Manchester University. Andrew has been particularly concerned with making the benefits of DNA technology available to people with genetic problems. He established one of the first DNA diagnostic laboratories in the UK over 20 years ago (it is now one of two National Genetics Reference Laboratories), and was founder chairman of the British Society for Human Genetics, the main professional body in this area. His own research is on the molecular pathology of various hereditary syndromes, especially hereditary hearing loss.

Table of Contents

Section 1. The Basics 1. DNA Structure and Gene Expression 2. Chromosome Structure and Function 3. Cells and Development 4. Genes in Pedigrees and Populations 5. Amplifying DNA: PCR and Cell-based DNA Cloning 6. Nucleic Acid Hybridization: Principles and Applications 7. Analyzing DNA and Gene Structure, DNA Variation and Expression Section 2. The Human Genome and its Relationship to Other Genomes 8. Genome Projects and Model Organisms 9. Organization of the Human Genome 10. Human Gene Expression 11. Instability of the Human Genome: Mutation and DNA Repair 12. Our Place in the Tree of Life Section 3. Mapping and Identifying Disease Genes and Mutations 13. Genetic Mapping of Mendelian Characters 14. Identifying Human Disease Genes 15. Mapping and Identifying Genes Conferring Susceptibility to Complex Diseases 16. Molecular Pathology 17. Cancer Genetics 18. Genetic Testing in Individuals and Populations Section 4. New Horizons: Into the 21st Century and Beyond 19. Beyond the Genome Project: Functional Genomics, Proteomics and Bioinformatics 20. Genetic Manipulation of Cells and Animals 21. New Approaches to Treating Disease.

Additional information

CIN0815341822VG
9780815341826
0815341822
Human Molecular Genetics by Tom Strachan (Newcastle University, UK)
Tom Strachan (Newcastle University, UK)
Used - Very Good
Hardback
Taylor & Francis Inc
20031121
696
N/A
Book picture is for illustrative purposes only, actual binding, cover or edition may vary.
This is a used book - there is no escaping the fact it has been read by someone else and it will show signs of wear and previous use. Overall we expect it to be in very good condition, but if you are not entirely satisfied please get in touch with us

Customer Reviews - Human Molecular Genetics