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Disease-Modifying Targets in Neurodegenerative Disorders Veerle Baekelandt (Katholieke Universiteit (KU) Leuven, Belgium)

Disease-Modifying Targets in Neurodegenerative Disorders By Veerle Baekelandt (Katholieke Universiteit (KU) Leuven, Belgium)

Disease-Modifying Targets in Neurodegenerative Disorders by Veerle Baekelandt (Katholieke Universiteit (KU) Leuven, Belgium)


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Disease-Modifying Targets in Neurodegenerative Disorders Summary

Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies by Veerle Baekelandt (Katholieke Universiteit (KU) Leuven, Belgium)

Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies examines specific neurodegenerative disorders in comprehensive chapters written by experts in the respective fields. Each chapter contains a summary of the disease management field, subsequently elaborating on the molecular mechanisms and promising new targets for disease-modifying therapies. This overview is ideal for neuroscientists, biomedical researchers, medical doctors, and caregivers, not only providing readers with a summary of the way patients are treated today, but also offering a glance at the future of neurodegenerative disorder treatment.

About Veerle Baekelandt (Katholieke Universiteit (KU) Leuven, Belgium)

Dr. Veerle Baekelandt obtained a Master of Romance Languages, Master of Biology, and a PhD in Biology at the Katholieke Universiteit (KU) Leuven. She received a Frank Boas Fulbright scholarship for graduate study at Harvard University and became a research fellow in the Laboratory for Neuroscience Research headed by Dr. Larry Benowitz, Childrens Hospital, Harvard Medical School, Boston (1992-1993). Her post-doctoral fellowship looked at gene therapy for neurodegenerative diseases, which became the cornerstone of her own research group.She was appointed Assistant Professor at the KU Leuven in 2003 and in 2007, as full-time Research Professor (BOF-ZAP). She is now Head of the Laboratory for Neurobiology and Gene Therapy. Her research focuses on disease modeling and therapy for Parkinsons disease using viral vectors in cell culture and in vivo. The underlying rationale is that the generation of more relevant models in cells and in pre-clinical model brain will lead to a better insight into the molecular pathogenesis of PD and to the development of new therapeutic strategies and drugs. Dr. Evy Lobbestael obtained her Masters degree in biomedical sciences in the Faculty of Medicine at the KU Leuven. She completed her PhD training in the laboratory for Neurobiology and Gene Therapy at the KU Leuven under the supervision of Prof. Baekelandt, after obtaining a PhD scholarship from the Research Foundation Flanders. Her doctoral research focused on the function and dysfunction of the Parkinsons disease-linked gene LRRK2. Besides the development of multiple tools to study LRRK2 including anti-LRRK2 antibodies, LRRK2-encoding lentiviral vectors, and cell lines, she identified protein phosphatase 1 as a physiological regulator of cellular LRRK2 phosphorylation. Currently, she continues her LRRK2 research as a post-doc with a focus on LRRK2 signaling.

Table of Contents

1. The multitude of therapeutic targets in neurodegenerative proteinopathies 2. Synuclein misfolding as a therapeutic target 3. Neuroinflammation as a therapeutic target in neurodegenerative diseases 4A. Stem cells in neurodegeneration: mind the gap 4B. The potential of stem cells in tackling neurodegenerative diseases 5. Preclinical models of Alzheimers disease for identification and preclinical validation of therapeutic targets: from fine-tuning strategies for validated targets to new venues for therapy 6. Parkinsons disease 7. Lewy body dementia 8. Frontotemporal dementia 9. From huntingtin gene toHuntingtons disease-altering strategies 10. Amyotrophic lateral sclerosis: mechanisms and therapeutic strategies

Additional information

NPB9780128051207
9780128051207
0128051205
Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies by Veerle Baekelandt (Katholieke Universiteit (KU) Leuven, Belgium)
New
Hardback
Elsevier Science Publishing Co Inc
2017-04-01
320
N/A
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