In this issue of Heart Failure Clinics, guest editors Drs. Vijay Rao and Geetha Bhatt bring their considerable expertise to the topic of Novel Non-pharmacological Approaches to Heart Failure. Recent years have seen a multitude of new devices and non-pharmacologic approaches to heart failure (HF), which, in the properly selected patient, can have significant impacts on morbidity and mortality. This issue provides a contemporary summary of these innovative approaches from leaders in the field. Contains 14 relevant, practice-oriented topics including barostimulation in HF; remote monitoring devices in HF; HIS bundle pacing in HF; A.fib ablation and HF (CASTLE-AF) and beyond; interatrial shunt devices; stem cell therapy in HF; novel approaches to sleep apnea in HF; and more. Provides in-depth clinical reviews on novel non-pharmacological approaches to heart failure, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.