Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors Volume editor Erkki Nissinen (Orion Corporation, Espoo, Finland)

Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors by Volume editor Erkki Nissinen (Orion Corporation, Espoo, Finland)

Name: Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors By Volume editor Erkki Nissinen (Orion Corporation, Espoo, Finland)
SKU: 9780123813268
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Summary

Focuses on Catechol-O-methyltransferase inhibition, and its clinical application in relation to Parkinson's disease. This title includes chapters that cover COMT gene and proteins, L-dopa treatment in Parkinson's disease, the latest research on COMT inhibitors and their clinical applications, as well as future prospects for their use.

Introductory remarks: Catechol-O-methyltransferase inhibition: an innovative approach to enhance L-dopa therapy in Parkinsons disease with dual enzyme inhibition Erkki Nissinen The catechol-O-methyltransferase gene, its regulation and polymorphisms Elizabeth M. Tunbridge Distribution and functions of catechol-O-methyltransferase proteins: do recent findings change the picture? Timo T. Myohanen & Pekka T. Mannisto Catechol-O-methyltransferase enzyme: Cofactor S-adenosyl-L-methionine and related mechanisms Thomas Muller Biochemistry and pharmacology of catechol-O-methyltrasferase inhibitors Erkki Nissinen and Pekka T. Mannisto The Chemistry of Catechol-O-methyltransferase Inhibitors David A. Learmonth, Laszlo E. Kiss and Patricio Soares-da-Silva Toxicology and safety of COMT inhibitors Kristiina Haasio Catechol-O-methyltransferase inhibitors in preclinical models as adjuncts of the L-dopa treatment Concepcio Marin, J.A. Obeso Problems with the present inhibitors and a relevance of new and improved COMT inhibitors in Parkinsons disease Seppo Kaakkola Catechol-O-methyltransferase and pain Oleg Kambur & Pekka T. Mannisto

Sku

NPB9780123813268

ISBN 13

9780123813268

ISBN 10

0123813263

Title

Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors: Volume 95 by Volume editor Erkki Nissinen (Orion Corporation, Espoo, Finland)

Author

Volume editor Erkki Nissinen (Orion Corporation, Espoo, Finland)

Condition

New

Binding type

Hardback

Publisher

Elsevier Science Publishing Co Inc

Year published

2010-12-14

Number of pages

336

Prizes

N/A

Cover note

Book picture is for illustrative purposes only, actual binding, cover or edition may vary.

Note

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Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors Volume editor Erkki Nissinen (Orion Corporation, Espoo, Finland)

Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors by Volume editor Erkki Nissinen (Orion Corporation, Espoo, Finland)

Summary

Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors Summary

Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors: Volume 95 by Volume editor Erkki Nissinen (Orion Corporation, Espoo, Finland)

Table of Contents

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