1. The Endocannabinoid Signaling System in the CNS: A Primer Cecilia J. Hillard 2. Evidence for a Role of Adolescent Endocannabinoid Signaling in Regulating HPA Axis Stress Responsivity and Emotional Behaviour Development Tiffany T.-Y. Lee and Boris B. Gorzalkas 3. The Endocannabinoid System and its Role in Regulating the Intrinsic Neural Circuitry of the Gastrointestinal Tract Samantha M. Trautmann and Keith A. Sharkey 4. Endocannabinoid Mechanisms Influencing Nausea Martin A. Sticht, Erin M. Rock, Cheryl L. Limebeer and Linda A. Parker 5. Endocannabinoid Regulation of Neuroendocrine Systems Jeffrey G. Tasker, Chun Chen, Marc O. Fisher, Xin Fu, Jennifer R. Rainville, and Grant L. Weiss 6. The Role of the Brain's Endocannabinoid System in Pain and its Modulation by Stress Louise Corcoran, Michelle Roche and David P. Finn 7. Endocannabinoid Signaling in Motivation, Reward and Addiction: Influences on Mesocorticolimbic Dopamine Function Claudia Sagheddu, Anna Lisa Muntoni, Marco Pistis and Miriam Melis