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Diversity and Functions of GABA Receptors: A Tribute to Hanns Mohler, Part A Volume editor Uwe Rudolph (Genetic Neuropharmacology Laboratory, McLean Hospital, Belmont, MA, USA)

Diversity and Functions of GABA Receptors: A Tribute to Hanns Mohler, Part A By Volume editor Uwe Rudolph (Genetic Neuropharmacology Laboratory, McLean Hospital, Belmont, MA, USA)

Diversity and Functions of GABA Receptors: A Tribute to Hanns Mohler, Part A by Volume editor Uwe Rudolph (Genetic Neuropharmacology Laboratory, McLean Hospital, Belmont, MA, USA)

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Diversity and Functions of GABA Receptors: A Tribute to Hanns Mohler, Part A Summary

Diversity and Functions of GABA Receptors: A Tribute to Hanns Mohler, Part A: Volume 72 by Volume editor Uwe Rudolph (Genetic Neuropharmacology Laboratory, McLean Hospital, Belmont, MA, USA)

This new volume of Advances in Pharmacology presents the diversity and functions of GABA Receptors. The volume looks at research performed in the past 20 years which has revealed specific physiological and pharmacological functions of individual GABAA receptor subtypes, providing novel opportunities for drug development.

Diversity and Functions of GABA Receptors: A Tribute to Hanns Mohler, Part A Reviews

Praise for the Series: "...recommended not only to pharmacologists but also to all those in related disciplines" --Nature

About Volume editor Uwe Rudolph (Genetic Neuropharmacology Laboratory, McLean Hospital, Belmont, MA, USA)

Dr. Rudolph is Director of the Laboratory of Genetic Neuropharmacoloy at McLean Hospital and Professor of Psychiatry at Harvard Medical School. He studied medicine and completed a research thesis on G proteins at the Freie Universitat Berlin, Germany. After postdoctoral training at Baylor College of Medicine in Houston, Texas, where he developed a mouse model of inflammatory bowel disease and colon cancer, he moved to the Institute of Pharmacology and Toxicology of the University of Zurich to work on GABAA receptors. There, he developed different lines of knock-in mice in which diazepam-sensitive GABAA receptor subtypes were rendered insensitive to diazepam by a histidine to arginine point mutation. Studying these mice enables researchers to uncover unique functional roles of GABAA receptor subtypes. In 2005, he joined McLean Hospital in Belmont, MA, and Harvard Medical School, where his research group is elucidating the functions of GABAA receptor subtypes in defined neuronal populations.

Table of Contents

1.The Legacy of the Benzodiazepine Receptor: From Flumazenil to Enhancing Cognition in Down Syndrome and Social Interaction in Autism Hanns Mohler 2.Behavioral Functions of GABAA Receptor Subtypes the Zurich Experience Florence Crestani and Uwe Rudolph 3.Allosteric Modulation of GABAA Receptors via Multiple Drug Binding Sites Werner Sieghart 4.Regulation of GABAARs by Phosphorylation Yasuko Nakamura, Laura M. Darnieder, Tarek Z. Deeb and Stephen J. Moss 5.Endozepines Zoya Farzampour, Richard J. Reimer and John Huguenard 6.Inhibitory Neurosteroids and the GABAA Receptor Sandra Seljeset, Duncan Laverty and Trevor G Smart 7.Interactions of Flavonoids with Ionotropic GABAA Receptors Jane R Hanrahan, Mary Chebib and Graham A R Johnston 8.GABAA Receptor Partial Agonists and Antagonists: Structure, Binding Mode, and Pharmacology Jacob Krall, Thomas Balle, Niels Krogsgaard-Larsen, Troels E. Srensen, Povl Krogsgaard-Larsen, Uffe Kristiansen and Bente Frlund 9.Closing the Gap between the Molecular and Systemic Actions of Anesthetic Agents Bernd Antkowiak

Additional information

NPB9780128026601
9780128026601
012802660X
Diversity and Functions of GABA Receptors: A Tribute to Hanns Mohler, Part A: Volume 72 by Volume editor Uwe Rudolph (Genetic Neuropharmacology Laboratory, McLean Hospital, Belmont, MA, USA)
Volume editor Uwe Rudolph (Genetic Neuropharmacology Laboratory, McLean Hospital, Belmont, MA, USA)
New
Hardback
Elsevier Science Publishing Co Inc
2015-01-13
282
N/A
Book picture is for illustrative purposes only, actual binding, cover or edition may vary.
This is a new book - be the first to read this copy. With untouched pages and a perfect binding, your brand new copy is ready to be opened for the first time

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