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Handbook of Basic Pharmacokinetics... Including Clinical Applications Wolfgang A. Ritschel

Handbook of Basic Pharmacokinetics... Including Clinical Applications By Wolfgang A. Ritschel

Handbook of Basic Pharmacokinetics... Including Clinical Applications by Wolfgang A. Ritschel


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Summary

Dealing with the pharmacokinetic principles and techniques, this title includes chapters such as: Absorption/Transport Mechanisms, Physicochemical and Biological Factors Affecting In Vivo Performance of Drugs, Drug Biotransformation, Excretion and Clearance of Drugs, Pediatric Pharmacokinetics, First-Dose Size in Man, and Pharmacogenetics.

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Handbook of Basic Pharmacokinetics... Including Clinical Applications Summary

Handbook of Basic Pharmacokinetics... Including Clinical Applications by Wolfgang A. Ritschel

First published in 1976, the Handbook of Basic Pharmacokinetics...Including Clinical Applications is known for being a user-friendly consolidation of pharmacokinetic principles and techniques for practitioners, researchers, and students that merits a place in any personal or college library. In this seventh edition, 10 chapters have been substantially revised to address recent developments and incorporate new information, illustrations, and equations and up-to-date literature citations. The appendix has been expanded to include parameters for some 150 additional drugs, bringing the total to more than 790.

Key Features:
  • Chapters on the following topics have been updated: Absorption/Transport Mechanisms, Physicochemical and Biological Factors Affecting in vivo Performance of Drugs, Drug Biotransformation, Excretion and Clearance of Drugs, Pediatric Pharmacokinetics, First-Dose Size in Man, Correlation of Clinical Response with Drug Disposition, Bioavailability and Bioequivalence, Extracorporeal Methods of Drug Removal, and Pharmacogenetics and Pharmacogenomics.
  • More than 100 pharmacokinetic terms are defined in Chapter 1.
  • Pharmacokinetic data compiled from the literature on nearly 800 drugs-150 new to this edition-are presented in the tabular appendix.

About Wolfgang A. Ritschel

Wolfgang A. Ritschel, PhD, MD, Mr Pharm, FASA, FCP, Professor Emeritus of Pharmacokinetics and Biopharmaceutics, University of Cincinnati College of Pharmacy and Professor Emeritus of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Gregory L. Kearns, PharmD, PhD, FCP, Marion Merrell Dow/Missouri Chair in Pediatric Medical Research; Professor of Pediatrics and Pharmacology, University of Missouri-Kansas City; Chairman, Department of Medical Research, Vice Chairman, Department of Pediatrics, and Director, Pediatric Pharmacology Research Unit, Children's Mercy Hospitals and Clinics, Kansas City, Missouri.

Table of Contents

  • 1. Definitions and Glossary.
  • 2. The LADMER System: Drug Liberation, Absorption, Distribution, Metabolism, Elimination, and Response.
  • 3. Organs, Tissues, Cells, and Organelles.
  • 4. Cell Membranes-Structure, Functions, and Properties.
  • 5. Drug Receptor Interactions.
  • 6. Absorption/Transport Mechanisms.
  • 7. PKa and Degree of Ionization.
  • 8. Lipid/Water Partition Coefficient.
  • 9. Physico-Chemical Factors Altering Biological Perfor-
  • mance of Drugs.
  • 10. Biopharmaceutical Data of the Gastrointestinal Tract.
  • 11. Fluid Compartments and Circulatory System (Blood
  • and Lymph).
  • 12. Binding of Drugs to Biological Material
  • 13. Drug Biotransformation.
  • 14. Compartment Models.
  • 15. Determination of Rate Constants.
  • 16. Volume of Distribution and Distribution Coefficient.
  • 17. Excretion and Clearance of Drugs.
  • 18. Urinary and Biliary Recycling.
  • 19. Cumulative Urinary Excretion.
  • 20. Area Under the Blood Level-Time Curve.
  • 21. Pharmacokinetics of Single Dose Administration.
  • 22. Pharmacokinetics of Multiple Dosing.
  • 23. Compartment Model Independent Analysis.
  • 24. Pediatric Pharmacokinetics.
  • 25. Drug Dosage in Elderly Patients.
  • 26. Drug Dosage in Obese Patients.
  • 27. Drug Disposition in Pregnancy.
  • 28. Dosage Regimen Design.
  • 29. Drug Monitoring and Dose Adjustment.
  • 30. Physiological and Pathological Factors Influencing Drug
  • Response.
  • 31. First Dose Size in Man.
  • 32. Forensic Pharmacokinetics.
  • 33. Nonlinear Pharmacokinetics.
  • 34. Curve Fitting.
  • 35. Correlation of Clinical Response with Drug Disposition.
  • 36. Bioavailability and Bioequivalence.
  • 37. Body Surface Area.
  • 38. Extracorporeal Methods of Drug Removal.
  • 39. Pharmacogenetics and Pharmacogenomics.
  • Appendix.
  • Index.

Additional information

CIN1582121265G
9781582121260
1582121265
Handbook of Basic Pharmacokinetics... Including Clinical Applications by Wolfgang A. Ritschel
Used - Good
Hardback
American Pharmacists Association
20090909
490
N/A
Book picture is for illustrative purposes only, actual binding, cover or edition may vary.
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