This book provides a self-study program on how mathematics, computer science and science can be usefully and seamlessly intertwined. Learning to use ideas from mathematics and computation is essential for understanding approaches to cognitive and biological science. As such the book covers calculus on one variable and two variables and works through a number of interesting first-order ODE models. It clearly uses MatLab in computational exercises where the models cannot be solved by hand, and also helps readers to understand that approximations cause errors a fact that must always be kept in mind.